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Johnson & Johnson: Booster Provides ‘Rapid & Robust’ COVID Antibodies

Boosters are being planned in the United States as early as the fall for those who got the two-shot Pfizer-BioNTech and the Moderna vaccines. The third vaccine maker, Johnson & Johnson, said Wednesday that studies show a booster shot of its vaccine provides a “rapid and robust increase” in Covid-19 antibodies when used on people who have already received its first dose. J&J says that neutralizing antibody responses from its single-shot dose have been shown to hold up for eight months after immunization. And experts say that the evidence suggests the vaccine appears to be doing its primary job of keeping Covid patients out of hospitals and morgues.

The interim data showed people who already had been given the J&J vaccine experienced a ninefold increase in spike-binding antibodies compared with 28 days after the first dose, the drugmaker said in a statement. That increase was seen in trial participants ages 18 to 55, and in people over 65 who received a lower booster dose, according to the statement. The study was done early in anticipation of the need for boosters, the company said.

Brandon Rivera, a Los Angeles County emergency medical technician, gives a dose of the Covid-19 vaccine to Aaron Delgado, 16, at a pop-up vaccine clinic in the Arleta neighborhood of Los Angeles, California, on August 23, 2021. – The US Food and Drug Administration on August 23, fully approved the Pfizer-BioNTech Covid shot, triggering a new wave of vaccine mandates as the Delta variant batters the country. Around 52 percent of the American population is fully vaccinated, but health authorities have hit a wall of vaccine-hesitant people, impeding the national campaign. (Photo by Robyn Beck / AFP) (Photo by ROBYN BECK/AFP via Getty Images)

Real-world data shows that J&J’s shot holds up against the Delta variant. A huge study of health workers in South Africa showed the vaccine remained 71 percent protective against hospitalization from the variant and between 91 percent and 96 percent effective against death. And the researchers said the vast majority of breakthrough infections in vaccinated people were mild.

But last week U.S. Surgeon General Vivek Murthy said boosters “will likely be needed” for the J&J vaccine. And some Americans have already sought out additional doses of Covid vaccines after getting the J&J shot, essentially mixing and matching shots from different companies.

The J&J findings announced Wednesday showed a booster of the same type gave a sharp increase in the number of binding antibodies. Unlike neutralizing antibodies, which destroy the virus, binding antibodies attach to the virus but do not destroy it or prevent infection. Instead, they alert the immune system of its presence so white blood cells can be sent to destroy it.

The results were released ahead of long-awaited results from J&J’s large, two-dose vaccine trial. Mathai Mammen, global head of Janssen Research & Development at Johnson & Johnson, said the company was looking “forward to discussing with public health officials a potential strategy” for deploying a J&J booster shot.



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