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FDA Authorizes Mix-And-Match Approach to COVID Boosters

FDA Authorizes Mix-And-Match Approach to COVID Boosters

COVID virus is surging

The Food and Drug Administration (FDA) on Wednesday gave its approval for Americans to get booster shots that are different from the COVID vaccine they initially received.

As we previously reported, the FDA released findings from their study proving the so-called “mix-and-match” approach to booster shots to be just as, if not more, effective than getting a matching booster. Acting FDA Commissioner Janet Woodcock said that the new recommendation is important for “continued protection” against COVID-19, citing data that suggest immunity in fully vaccinated people wanes over time. About 77% of the eligible U.S. population have received at least one dose of the vaccine, per the CDC.

[Photo by CHANDAN KHANNA/AFP via Getty Images]
The recommendation from the FDA, which also authorized booster shots for people who received Moderna and Johnson & Johnson vaccines on Wednesday, paves the way for an expansion of booster shots. People who received a shot of Johnson & Johnson’s vaccine have a stronger neutralizing antibody response if they receive an mRNA shot instead of a second J&J one, according to NIH data presented to a key FDA advisory committee.

As recommended by the FDA, Moderna boosters (which are half of the dose that is administered for a primary series dose) may be given six months after completing the two-dose series, while J&J boosters may be given as soon as two months after the initial jab The FDA recommends the Moderna booster for anyone 65 and older or those over 18 with a higher risk of severe COVID or exposure to the virus, and the J&J booster is recommended for anyone over the age of 18.


A CDC advisory panel will review the boosters and issue its own recommendations. Once they issue their final approval, people will be able to get their boosters within days.

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